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Low back pain can often be caused by ligament injury, leading to instability of the lower lumbar spine and sacroiliac joint (SIJ). Using hypertonic dextrose-based prolotherapy and/or platelet-rich plasma (PRP), these structures can be repaired, restoring stability to the lower back. This can be a very effective non-surgical approach to SIJ dysfunction in combination with PT, without the need for steroids or surgery.